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benzinga Corporate Catalyst Impact 55/100 ● negative

Wedbush Maintains Outperform on Spyre Therapeutics, Lowers Price Target to $123

Aug 26, 2026, 12:38 PM UTC · Primary ticker $SYRE

Wedbush analyst David Nierengarten maintained an 'Outperform' rating on Spyre Therapeutics but lowered the price target from $130 to $123. This indicates a slightly reduced but still positive outlook for the company's stock.

Wedbush analyst David Nierengarten reiterated an 'Outperform' rating for Spyre Therapeutics, signaling continued confidence in the company's long-term prospects. However, the price target was adjusted downwards from $130 to $123, suggesting a slight recalibration of valuation expectations. This move could be due to various factors, such as updated financial models, competitive landscape changes, or broader market conditions impacting the biotech sector. For traders, this news presents a neutral to slightly negative short-term signal, as the lowered price target might temper immediate upside expectations, but the maintained 'Outperform' rating suggests underlying strength. The long-term implications remain positive, assuming the analyst's fundamental assessment holds true, but the reduced target introduces a degree of caution.

$SYRE neutral Analyst rating maintained, price target lowered
Source: benzinga
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Not financial advice. AI-generated analysis for informational purposes only.